MMP Red 基质金属蛋白酶红色荧光底物

产品基本信息

产品名称：MMP Red 基质金属蛋白红色荧光底物

储存条件：-15℃避光防潮

保质期：24个月

 

产品物理化学光谱特性

分子量：~2000

溶剂：DMSO

激发波长(nm)：545

发射波长(nm)：576

 

产品介绍

MMP Red 基质金属蛋白红色荧光底物是美国AAT Bioquest生产的用于检测MMP的试剂，基质金属蛋白酶(MMPs)组成了锌依赖的内肽酶家族，它们是细胞外基质中发挥重要的作用。这些酶造成结缔组织的断裂，并且在骨骼重塑、月经周期和坏损组织的修复中发挥着重要作用。目前，对MMPs在生理功能中的具体作用还难以评定，但是也发现其在关节炎的形成，癌症的浸入和转移中发挥关键作用。MMPs具有多种底物，这些家族成员中的大部分成员都可以降解不同类型的胶原蛋白，这些胶原蛋白通常与弹力素，凝胶和纤粘蛋白一起。很难找到一种选择性的单一MMP酶底物。该试剂盒内的FRET底物是是用于检测一种MMP酶活性的底物，也可结合纯化的MMP蛋白，被用于MMP酶抑制剂的筛选。该FRET底物是基于AAT Bioquest的TF2/TQ2 FRET对，当MMP催化水解其底物时，TF2/TQ2 FRET对分离，这样FRET多肽底物MMP Red的荧光强度增加，相应的其荧光强度与MMP酶活性成比率，以获得其活性数值。百萤生物是AAT Bioquest的中国代理商，为您提供优质的MMP Red 基质金属蛋白红色荧光底物。 

点击查看光谱

 

参考文献

Zinc ions regulate opening of tight junction favouring efflux of macromolecules via the GSK3β/snail-mediated pathway
Authors: Ruyue Xiao, Lan Yuan, Weijiang He, Xiaoda Yang
Journal: Metallomics (2018)

Connexin 43 Upregulation by Dioscin Inhibits Melanoma Progression via Suppressing Malignancy and Inducing M1 Polarization
Authors: Yu Kou, Liyan Ji, Haojia Wang, Wensheng Wang, Hongming Zheng, Juan Zou, Linxin Liu, Xiaoxiao Qi, Zhongqiu Liu, Biaoyan Du
Journal: International Journal of Cancer (2017)

DACT2, an epigenetic stimulator, exerts dual efficacy for colorectal cancer prevention and treatment
Authors: Linlin Lu, Ying Wang, Rilan Ou, Qian Feng, Liyan Ji, Hongming Zheng, Yue Guo, Xiaoxiao Qi, Ah-Ng Tony Kong, Zhongqiu Liu
Journal: Pharmacological research (2017)

Probing Cell Adhesion Profiles with a Microscale Adhesive Choice Assay
Authors: Harsha Kittur, Andy Tay, Avery Hua, Min Yu, Dino Di Carlo
Journal: Biophysical Journal (2017): 1858--1867

Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE-/- mice
Authors: Qiong Duan, Xiaoxiao Mao, Chaonan Liao, Haoyang Zhou, Zelin Sun, Xu Deng, Qiuning Hu, Jun Qi, Guogang Zhang, He Huang
Journal: International Journal of Cardiology (2016): 428--432

Tissue inhibitor of metalloproteinase 1 influences vascular adaptations to chronic alterations in blood flow
Authors: Erin R Mandel, Cassandra Uchida, Emmanuel Nwadozi, Armin Makki, Tara L Haas
Journal: Journal of Cellular Physiology (2016)

β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines
Authors: Silvia Moretti, Daniela Massi, Valentina Farini, Gianna Baroni, Matteo Parri, Stefania Innocenti, Roberto Cecchi, Paola Chiarugi
Journal: Laboratory Investigation (2013): 279--290

Matrix Remodeling Maintains Embryonic Stem Cell Self-Renewal by Activating Stat3
Authors: Laralynne M Przybyla, Thorold W Theunissen, Rudolf Jaenisch, Joel Voldman
Journal: Stem Cells (2013): 1097--1106

Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes
Authors: S Delic, N Lottmann, K Jetschke, G Reifenberger, Markus J Riemenschneider
Journal: Neuropathology and applied neurobiology (2012): 201--212

EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells
Authors: Maria Letizia Taddei, Matteo Parri, Adriano Angelucci, Francesca Bianchini, Chiara Marconi, Elisa Giannoni, Giovanni Raugei, Mauro Bologna, Lido Calorini, Paola Chiarugi
Journal: Molecular Cancer Research (2011): 149--160

 

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