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柯胺G CAS 6472-91-9

英文名称:Chrysamine G *CAS 6472-91-9*
产品参数
Ex (nm)-Em (nm)-
分子量482.44溶剂DMSO
存储条件在零下15度以下保存, 避免光照
产品概述

产品基本信息

产品名称:柯胺G

CAS:6472-91-9

储存条件:-15℃避光防潮

保质期:24个月

 

产品物理化学光谱特性

分子量:482.44

溶剂:DMSO

激发波长(nm):386

发射波长(nm):N/A

 

产品介绍

Chrysamine G是刚果红的亲脂性双水杨酸类似物,具有高(Kd = 200 nM; Bmax = 1.13摩尔/摩尔Ab40)和低(Kd = 38.77 µM; Bmax = 23.10摩尔/摩尔Ab40)。 β-淀粉样蛋白(Ab)原纤维的亲和力结合位点。 它可以穿过血脑屏障,并可用作检测老年斑(Ab聚集体)的有用探针。百萤生物是AAT Bioquest的中国代理商,为您提供优质的柯胺G。 

 

参考文献

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
Authors: Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.
Journal: J Biol Chem (2005): 5892

Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
Authors: Mathis CA, Wang Y, Klunk WE.
Journal: Curr Pharm Des (2004): 1469

Amyloid binding ligands as Alzheimer's disease therapies
Authors: Lee VM.
Journal: Neurobiol Aging (2002): 1039

Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice
Authors: Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H.
Journal: Neurosci Lett (2002): 5

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
Authors: Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.
Journal: J Neuropathol Exp Neurol (2002): 797

Evaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis
Authors: Dezutter NA, L and man WJ, Jager PL, de Groot TJ, Dupont PJ, Tooten PC, Zekarias B, Gruys E, Verbruggen AM.
Journal: Amyloid (2001): 202

In search of the ideal radiotracer for soft-tissue amyloid scanning
Authors: Lee VW, Shah NP.
Journal: Amyloid (2001): 220

In vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis
Authors: Dezutter NA, Sciot RM, de Groot TJ, Bormans GM, Verbruggen AM.
Journal: Nucl Med Commun (2001): 553

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles
Authors: Smith DL, Portier R, Woodman B, Hockly E, Mahal A, Klunk WE, Li XJ, Wanker E, Murray KD, Bates GP.
Journal: Neurobiol Dis (2001): 1017

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
Authors: Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE.
Journal: Proc Natl Acad Sci U S A (2000): 6739